Genome editing
Type of genetic engineering
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| May 2025 | ISTT maintains two mailing lists: the public transgenic-list (tg-l) with approximately 1500 participants and the ISTT-list for members with around 700 participants. |
| 2025 | Awarded the National Medal of Technology and Innovation. |
| 2025 | Rudolf Jaenisch awarded the ISTT Prize, recognizing his exceptional work in transgenic technologies at the Transgenic Technology Meeting. |
| 2025 | International Society for Transgenic Technologies conference scheduled to be held in Zurich, Switzerland |
| 2024 | Received the Golden Plate Award from the American Academy of Achievement and was elected as a Foreign Member of the Royal Society. |
| April 2024 | The ISTT maintains two mailing lists: a public transgenic-list with approximately 1500 participants and an ISTT-list for members with around 660 participants. |
| March 2024 |
CRISPR gene editing
Researchers from the University of Amsterdam reported the elimination of HIV in cell cultures using a new CRISPR therapy.
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| 2023 |
Designer baby
After his release from prison, He Jiankui shifted his research focus to treating genetic diseases, including Duchenne muscular dystrophy (DMD).
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| 2023 | Received an honorary Doctor of Science degree from Harvard. |
| 2023 | Inducted into the National Inventors Hall of Fame. |
| 2023 |
Gene drive
Cas12a gene drives were successfully tested, expanding the range of endonuclease technologies for gene drive applications.
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| 2023 | International Society for Transgenic Technologies conference held in Houston, USA |
| 2023 | Rebecca Haffner-Krausz becomes President of the International Society for Transgenic Technologies, succeeding Ernst Martin Füchtbauer |
| December 2023 |
CRISPR gene editing
The FDA approved two milestone treatments for Sickle Cell Disease: Casgevy and Lyfgenia, representing the first cell-based gene therapies in the US.
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| December 8 2023 |
CRISPR gene editing
The U.S. Food and Drug Administration approved Casgevy for use in the United States, marking a significant milestone in CRISPR-based medical treatments.
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| November 2023 |
CRISPR gene editing
The UK's Medicines and Healthcare products Regulatory Agency (MHRA) became the first globally to approve Casgevy, the first drug based on CRISPR gene editing, for treating sickle-cell anemia and beta thalassemia.
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| October 2023 |
CRISPR gene editing
An early-stage study on EBT-101 involving 3 people reported that the treatment appeared to be safe with no major side effects, though no effectiveness data was disclosed.
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| September 2023 |
Designer baby
He Jiankui was appointed as the inaugural director of the Genetic Medicine Institute at Wuchang University of Technology in Wuhan after being released from prison.
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| September 8 2023 | He Jiankui was appointed as the inaugural director of the Institute of Genetic Medicine at a private undergraduate college in Wuhan, Hubei. |
| February 21 2023 | Ming Pao newspaper reported that He Jiankui claimed his application for a Hong Kong entry permit through the Top Talent Pass Scheme had been approved. However, the Hong Kong Government later announced that the Immigration Department suspected false statements and invalidated his entry permit, initiating a criminal investigation. |
| January 2023 |
CRISPR gene editing
Casgevy, the first drug using CRISPR gene editing, was approved for use in the United Kingdom to treat sickle-cell disease and beta thalassemia.
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| 2022 | Release of documentary 'Make People Better' directed by Cody Sheehy, which describes He Jiankui's disappearance after creating the first designer babies and shocking the scientific community. |
| 2022 |
CRISPR gene editing
Researchers demonstrated a new CRISPR-Cas9 technique combined with integrases that enabled gene delivery without double-stranded breaks, potentially useful for treating diseases caused by multiple mutations. The method could deliver genes as long as 36,000 DNA base pairs to several types of human cells.
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| 2022 |
CRISPR gene editing
Clinical trials of EBT-101, a CRISPR–Cas9 based HIV therapy, commenced in humans.
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| 2022 |
CRISPR gene editing
Introduction of SuperFi-Cas9, a more accurate gene editing protein that maintains high-speed performance.
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| 2022 |
CRISPR gene editing
Development of Cas7-11 for RNA editing purposes.
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| 2022 |
CRISPR gene editing
Research on chromosome-templated DNA repair method using Cas9-derived nickases, demonstrated to be more effective with fewer off-target edits.
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| 2022 | Joined Sixth Street Partners as their chief science advisor, focusing on guiding investment decisions related to CRISPR technology. |
| 2022 |
Gene drive
Researchers developed t-CRISPR, a gene drive technique that could pass the 't haplotype' gene to about 95% of offspring, with models suggesting the ability to eliminate a mouse population of 200,000 by introducing just 256 altered animals over approximately 25 years.
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| 2022 | International Society for Transgenic Technologies conference held in Helsinki, Finland |
| 2022 |
Epigenome editing
Research explored epigenome editing applications for multiple medical conditions, including reducing tau protein levels, regulating proteins in Huntington's disease, targeting an inherited form of obesity, and addressing Dravet syndrome.
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| 2022 |
He Jiankui affair
The third genetically edited baby, named Amy, was revealed to the public.
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| December 2022 |
CRISPR gene editing
A 13-year-old British girl with incurable T-Cell Acute Lymphoblastic Leukaemia was cured using therapeutic gene editing at Great Ormond Street Hospital, marking the first documented use of this approach for her condition.
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| November 2022 |
CRISPR gene editing
Editas reported that 20% of the patients treated had significant improvements, but also announced that the resulting target population was too small to support continued independent development of the treatment.
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| November 24 2022 | He publicly stated his intention to develop gene therapies for three to five genetic diseases within two to three years, with a specific focus on Duchenne muscular dystrophy. |
| November 10 2022 | He announced the establishment of a new laboratory in Beijing focused on gene therapy for rare genetic diseases. |
| July 2022 |
CRISPR gene editing
Dosing of the new high-dose cohorts was expected to be completed by this time.
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| June 2022 |
CRISPR gene editing
UC Berkeley sold the NFT collection 'The Fourth Pillar' for 22 Ether.
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| April 2022 | Released from prison. |
| April 2022 |
He Jiankui affair
He Jiankui is released from prison.
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| March 2022 |
CRISPR gene editing
The USPTO ruled against the University of California, stating that the Broad Institute was first to file the CRISPR patent. This decision significantly impacted licensing agreements for CRISPR editing technology from UC Berkeley, with UC expressing intent to appeal the ruling.
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| February 2022 | Chinese scientists proposed building a special facility to care for and study the three CRISPR Babies, suggesting regular genome sequencing and testing. |
| February 2022 |
CRISPR gene editing
A phase 1 clinical trial was conducted for the VCTX210 diabetes treatment, with one patient volunteer receiving the CRISPR gene-edited stem cell therapy.
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| 2021 |
Designer baby
A scientific study revealed that polygenic risk scores explain only 5-10% of variance in educational attainment, critically examining the predictive limitations of genetic screening technologies.
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| 2021 |
Designer baby
The World Health Organization established a global registry for heritable genome editing practices to enhance transparency.
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| 2021 |
CRISPR
Researchers in China characterized novel miniature Cas13 protein variants Cas13X and Cas13Y. Using a small portion of SARS-CoV-2's N gene sequence, they demonstrated the sensitivity and specificity of mCas13 coupled with RT-LAMP for detecting SARS-CoV-2 in synthetic and clinical samples, showing superior performance compared to standard RT-qPCR tests.
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| 2021 | Publication of documentary book 'CRISPR People: The Science and Ethics of Editing Humans' by Henry Greely, further exploring He Jiankui's genetic modification experiment. |
| 2021 |
CRISPR gene editing
In a groundbreaking study, 9 out of 23 humanized mice treated with a combination of anti-retrovirals and CRISPR/Cas-9 had the HIV virus become undetectable, even after the typical rebound period. This result was unique, as neither treatment alone achieved the same effect.
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This contents of the box above is based on material from the Wikipedia articles CRISPR gene editing, He Jiankui, Jennifer Doudna, International Society for Transgenic Technologies, Gene drive, Epigenome editing, He Jiankui affair, Emmanuelle Charpentier, Prime editing, Designer baby & CRISPR, which are released under the Creative Commons Attribution-ShareAlike 4.0 International License.