Life extension
Concept of extending human lifespan by improvements in medicine or biotechnology
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| 2023 |
Stem-cell therapy
A case was published of a woman who developed Mycobacterium abscessus infection and meningitis after receiving stem cell treatment for multiple sclerosis at a commercial clinic in Baja California, Mexico.
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| 2023 | US Food and Drug Administration officially stated that no medication has been proven to slow or reverse the aging process, highlighting the current limitations in anti-aging drug research. |
| 2021 |
Stem-cell therapy
Stem cell injections in the US caused severe infections in at least 20 patients who received umbilical cord blood-derived products marketed as 'stem cell treatment'.
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| January 2021 |
Stem-cell therapy
The FDA approved the first clinical trial for an investigational stem cell therapy aimed at restoring lost brain cells in people with advanced Parkinson's disease.
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| 2020 |
Stem-cell therapy
A phase 2 clinical trial found significantly improved outcomes for patients with multiple sclerosis who were treated with mesenchymal stem cells compared to those receiving a sham treatment.
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| 2020 |
Stem-cell therapy
The FDA and FTC took action by sending warning letters to stem cell firms making misleading COVID-19-related marketing claims.
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| 2020 |
Stem-cell therapy
Some stem cell clinics began marketing unproven and non-FDA-approved stem cells and exosomes for COVID-19 treatment, despite NIH recommendations against such use.
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| 2020 | A research study quantified the global impact of air pollution on life expectancy, highlighting the potential for lifespan extension through environmental interventions. |
| 2020 | A study highlighted the potential impact of addressing common causes of death on extending human lifespans, emphasizing the importance of preventive healthcare strategies. |
| July 2020 | Researchers discovered that yeast cells with identical genetic material and in the same environment can age through two distinct processes. They described a biomolecular mechanism for determining aging routes and successfully genetically engineered a novel aging pathway that substantially extended lifespan. |
| July 2020 | Scientists used biological data from 1.75 million people to identify 10 genomic loci influencing healthspan, lifespan, and longevity, highlighting half as previously unreported findings. The study suggested that high blood iron levels may reduce lifespan, while genes involved in iron metabolism could potentially increase healthy years of life. |
| 2019 |
Stem-cell therapy
A scientific review highlighted the potential of stem cell-derived otic progenitors to significantly improve hearing regeneration, demonstrating promising advancements in regenerative medicine for cochlear hair cell regrowth.
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| 2018 |
Stem-cell therapy
The US Federal Trade Commission forced refunds of approximately $500,000 from health centers and a physician making unsubstantiated stem cell therapy claims.
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| 2018 |
Stem-cell therapy
The FDA filed lawsuits against two stem cell clinic firms, seeking permanent injunctions against their marketing of unapproved adipose stem cell products.
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| 2018 |
Stem-cell therapy
The European nTRACK research project began, aiming to develop a method for tracking stem cells in muscle regeneration therapy using multimodal nanoparticles. The research focused on labeling stem cells with gold nanoparticles to enable tracking through imaging systems during muscle injury treatment.
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| 2018 |
Stem-cell therapy
The TIME trial, using a randomized, double-blind, placebo-controlled design, concluded that bone marrow mononuclear cell administration did not improve left ventricular function recovery over 2 years in myocardial infarction patients.
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| 2018 |
Stem-cell therapy
The FDA sent a warning letter to StemGenex Biologic Laboratories in San Diego for marketing unproven stem cell treatments involving body fat processing and readministration.
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| 2018 |
Telomerase
UC Berkeley scientists determined the structure of human telomerase through cryo-EM.
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| January 2018 |
Somatic cell nuclear transfer
Scientists in Shanghai successfully cloned two female crab-eating macaques named Zhong Zhong and Hua Hua using foetal nuclei through somatic cell nuclear transfer.
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| 2016 |
Stem-cell therapy
Research revealed over 550 stem cell clinics in the United States selling generally unproven therapies for various medical conditions across almost every state.
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| 2015 |
Telomerase
The first cryo-electron microscopy (cryo-EM) structure of telomerase holoenzyme in Tetrahymena was determined.
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| 2015 | A global study revealed the mean loss of life expectancy from air pollution was 2.9 years, significantly higher than 0.3 years from all forms of direct violence. |
| 2014 |
Stem-cell therapy
A meta-analysis of bone marrow stem cell therapy for heart disease exposed significant discrepancies in clinical trial reports, with studies containing more discrepancies showing increased effect sizes.
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| 2014 | Neuroscientist Tony Wyss-Coray conducted blood exchange studies on mice, which were later misinterpreted by proponents of young blood treatments. |
| 2014 | Craig Venter founds Human Longevity Inc., a company dedicated to ending aging through genomics and cell therapy research, with the goal of creating a comprehensive human genotype, microbiome, and phenotype database. |
| 2013 |
Stem-cell therapy
Studies of autologous bone marrow stem cells revealed hundreds of discrepancies in reports about ventricular function, with serious issues in research methodology and data reporting identified.
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| 2013 |
Telomerase
Negative stain electron microscopy (EM) structures of human and Tetrahymena telomerases were characterized.
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| 2013 | Pew Research conducted a poll in the United States exploring public attitudes towards life extension, revealing complex perspectives on potential medical treatments that could extend human lifespan. |
| 2013 | Google announces Calico, a company focused on increasing scientific understanding of the biology of aging, led by Arthur D. Levinson and including scientists like Hal V. Barron, David Botstein, and Cynthia Kenyon. |
| July 2013 |
Stem-cell therapy
A previously closed university investigation into stem cell research was reopened to examine research irregularities.
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| 2012 |
Stem-cell therapy
Emergence of a second wave of stem cell therapy companies and clinics, primarily located in developing countries with less medical regulation, offering medical tourism-based stem cell treatments.
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| 2012 |
Growth hormone
Dragos Roman from the FDA commented in a Vanity Fair article about the discrepancy between HGH prescriptions and actual HGH-deficiency patients, highlighting the complex regulatory landscape of HGH usage.
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| 2012 | Longevity political parties were established in Russia, the United States, Israel, and the Netherlands, aiming to support radical life extension research and technologies, and facilitate societal transition to a potential future without aging. |
| 2011 | Sobh and Martin published research on consumer motivations for purchasing anti-aging products, exploring psychological drivers behind seeking life extension through product consumption. |
| 2010 |
Selegiline
Orally disintegrating tablet (ODT) form of selegiline receives approval in the European Union.
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This contents of the box above is based on material from the Wikipedia articles Life extension, Telomerase, Somatic cell nuclear transfer, Selegiline, Li A, Stem-cell therapy & Growth hormone, which are released under the Creative Commons Attribution-ShareAlike 4.0 International License.